So it has been a year or two, but I've been making sprite comics. I am planning on a new series, because my old ones were too long ago.
If you don't know what it is, this will tell you exactly what you need to know. Also, use that blank template for panels.
Here is a good website to find sprites if you want to make your own.
I am trying to find the ones I made back in '08, but you can make your own using these tools.
TIPS:
Save every template/character sheet/image in general as PNG. (Recoloring is easiest and theres no fuzzy off color bits like with JPG)
Turn opacity off in Paint when pasting images (should figure that out on your own)
Each comic for me takes approx. 2 hours. Save some time.
I'll add more tips soon, but for now you should be able to make some cool ones.
New (7/2/10) - Made this